They were more likely to have decreases in the number of days of bleeding (odds ratio, 2.4 95 percent confidence interval, 1.1 to 5.2), the amount of bleeding (odds ratio, 1.5 95 percent confidence interval, 1.1 to 2.0), and menstrual pain (odds ratio, 1.3 95 percent confidence interval, 1.0 to 1.8) and to have an increase in cycle irregularity (odds ratio, 1.6 95 percent confidence interval, 1.1 to 2.3). The women who had undergone sterilization were no more likely than those who had not undergone the procedure to report persistent changes in intermenstrual bleeding or the length of the menstrual cycle. Multiple logistic-regression analysis was used to assess the risk of persistent menstrual changes. All women were asked the same questions about six characteristics of their menstrual cycles in the presterilization and follow-up interviews. MethodsĪ total of 9514 women who underwent tubal sterilization and 573 women whose partners underwent vasectomy were followed in a multicenter, prospective cohort study for up to five years by means of annual telephone interviews. Collaborative Review of Sterilization to determine whether the likelihood of persistent menstrual abnormalities was greater among women who had undergone tubal sterilization than among women who had not. The existence of a post–tubal-ligation syndrome of menstrual abnormalities has been debated for decades. The most trusted, influential source of new medical knowledge and clinical best practices in the world.
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